Xenograft Model

Figure 1. Human tumor cells are transplanted subcutaneously in the back of nude mice.

The subcutaneous xenograft tumor model is the most common model for determining the in-vivo activity of therapeutic anticancer drugs. The antitumor effect of the test compound is evaluated by measuring and calculating the tumor volume of the tumor bearing mouse. The advantages of a human tumor xenograft model are: 1) being able to predict the drug response of a human patient’s tumor 2) it allows for the rapid assessment of the human tumor response in organs within a short time.