DISEASE AREA

Xenograft Model

Figure 1. Human tumor cells are transplanted subcutaneously in the back of nude mice.

The subcutaneous xenograft tumor model is the most common model for determining the in-vivo activity of therapeutic anticancer drugs. The antitumor effect of the test compound is evaluated by measuring and calculating the tumor volume of the tumor bearing mouse. The advantages of a human tumor xenograft model are: 1) being able to predict the drug response of a human patient’s tumor 2) it allows for the rapid assessment of the human tumor response in organs within a short time.