STAM™ Model

Our STAM™ model is a model that recapitulates the same disease progression as human MASH(f.k.a. NASH,hereinafter referred as MASH/NASH). In this model, male C57BL/6 mice aged two days are given a single dose of streptozotocin to reduce insulin secretory capacity. When the mice turn four weeks of age they start a high-fat diet feeding. This model has a background of late type 2 diabetes which progresses into fatty liver, MASH/NASH, fibrosis and consequently liver cancer (HCC). Compared to other MASH/NASH model mice, the disease progresses in a relatively short period of time, and liver cancer is developed in 100% of animals at 20 weeks of age. Thus, our model is widely used in MASH/NASH research, with more than 60 papers and 80 international conferences published using data from our STAM™ model so far.