• PUBLICATION

    Hyogo Medical University publishes HBV study featuring our histopathological analysis of hepatic steatosisNEW!!

    2023.03.22

    SMC is proud to announce that Hyogo Medical University (JPN) has published a study featuring histopathological data evaluated by our scientists here at SMC.

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  • PUBLICATION

    Study published in Cell Metabolism on the efficacy of MGAT2 inhibitor in STAM™

    2023.03.15

    SMC is proud to announce that Bristol-Myers Squibb (NJ) has published the results of their study using our pre-clinical services with the STAM™ model in Cell Metabolism.

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  • NEWS RELEASE

    March 9th is World Kidney Day!

    2023.03.08

    Today, in celebration of World Kidney Day, we would like to share with you a little bit about the campaigns history, as well as what the purpose of it is. World Kidney Day aims to raise awareness of the important role that　the kidney plays, as well as reduce kidney disease and other related health problems. The campaign is an initiative run by the International Society of Nephrology (ISN) and the International Federation of Kidney Foundations – World Kidney Alliance (IFKF-WKA), where they host many different events around the world with the goal of increasing public understanding of how to prevent kidney disease, recognize its risk factors and live with it.

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TOPICS

  • New Challenges, Explore New Ways!

    Just an Action responsibly will lead us to the best way.
    SMC is the Global Specialty CRO focuses on Non-clinical study.NEW!!

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  • re-START! Next Step to Future

    World together beyond COVID-19
    SMC is responding to the coronavirus disease (COVID-19) outbreak. The information center provides news, guidance and resources as well as the information of related area.

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  • Key Discoveries for new innovation

    The Global CRO specialized in Non-clinical trial.
    SMC provides the highest level of program management and clinical development services with the global value chain concept.

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  • STAM™ Model

    Our STAM™ model is a model that recapitulates the same disease progression as human NASH/HCC. In this model, male C57BL/6 mice aged two days are given a single dose of streptozotocin to reduce insulin secretory capacity. When the mice turn four weeks of age they start a high-fat diet feeding. This model has a background of late type 2 diabetes which progresses into fatty liver, NASH, fibrosis and consequently liver cancer (HCC). Compared to other NASH-HCC model mice, the disease progresses in a relatively short period of time, and liver cancer is developed in 100% of animals at 20 weeks of age. Thus, our model is widely used in NASH research, with more than 60 papers and 80 international conferences published using data from our STAM™ model so far.

Our Original Patented "STAM™ mice" Technology

We contribute to society through state-of-the art non-clinical pharmacological research using our patented "STAM™ mice" technology
In order to develop new drugs, it is important to be able to accurately measure the effectiveness of drug candidates at a nonclinical trial stage.
Our "STAM™ mice" are disease model mice that more accurately reflect human pathology and therefore play a major role in pharmacology studies.

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SMC Laboratories Service

  • SERVICE

    CRO & CONSULTING INFO.

    We support more than 1,000 pharmaceutical companies and bio-ventures in over 30 countries with our cutting-edge research and pharmacology studies.

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  • SERVICE

    THERAPEUTIC AREAS

    Thanks to our extensive experience in various treatment fields, we are able to provide quick and decisive support for our client's pharmacological studies.

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  • SERVICE

    HISTOLOGY

    Our expert pathologists support the construction of experimental analysis systems, data acquisition and explanation of results, and maximize the information from the histology samples of pharmacology studies conducted by clients.

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  • TRIAL

    TRIAL

    Clients are able to perform preliminary research using both blood samples and various other biospecimens from the disease model mice that SMC offer.

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