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UUO Model

The Unilateral Ureteral Obstruction (UUO) model is widely used as a model for renal fibrosis. This model demonstrates the pathological features of chronic kidney disease such as interstitial fibrosis, tubular atrophy, and inflammatory cell infiltration. It is also suitable for in-vivo screening tests for renal fibrosis due to the short test duration of two weeks.

Figure 1. UUO model, image of a Sirius Red stained kidney.
In comparison to normal mice, interstitial fibrosis is observed in the UUO model.