Today, we give you a brief introduction to the dextran sulfate sodium (DSS) -induced colitis model, which is a clinically representative mouse model that can be used to conduct drug efficacy studies targeting Inflammatory Bowel Disease.

This model is widely used to elucidate the mechanism of IBD pathogenesis and evaluate drug candidates because of its rapidity, simplicity and many similarities with human IBD. Here at SMC, we are capable of providing different 2 modes of colitis to conduct studies tailored to the needs of our clients and the mode of action of the test substance.

Acute colitis :
The model is good for evaluating the anti-inflammatory effects of your product candidate.

Histological features similar to those observed in human IBD, such as mucin and goblet cell depletion, epithelial erosion and an influx of inflammatory cells into lamina propria, can be observed by administering DSS in drinking water for 5 days.

Chronic colitis :
The model is good for evaluating the anti-fibrotic effects of your product candidate.

Intestinal fibrosis is established by 5 days of DSS exposure followed by 14 days of housing without DSS exposure.

If you found the above information interesting and would like to learn more about our DSS model, please do not hesitate to contact us.

I would also be happy to arrange a Zoom meeting where you can have the chance to discuss with our marketing and science team about our services and how we might assist your project. If this is something you might be interested in, please feel free to let me know.