Study published in Cell Metabolism on the efficacy of MGAT2 inhibitor in STAM™
- 2023.03.15
- PUBLICATION
SMC is proud to announce that Bristol-Myers Squibb (NJ) has published the results of their study using our pre-clinical services with the STAM™ model in Cell Metabolism.
Title
(Cheng et al., Cell Metab 2022)
The above article reviews the effect of Bristol-Myers Squibb’s compound, BMS-963272 (Monoacylglycerol acyltransferase 2 (MGAT2) inhibitor), in the STAM™ model from week 6 to week 9, where the mice develop a similar pathology to the early stages of NASH.
The STAM™ mice have a type 2 diabetic background and spontaneously develop fatty liver, which progresses to NASH, fibrosis, and finally ends in liver cancer (hepatocellular carcinoma).
The results from this study showed that BMS-963272 tended to decrease the NAFLD activity score and was able to significantly reduced liver fibrosis and plasma TNF-α levels when compared to the vehicle group. These results indicate that BMS-963272 has a therapeutic effect on NASH by reducing both inflammation and fibrosis.
Are you considering conducting a study to evaluate the efficacy of your compound in NASH? Then why not consider evaluating it in a clinically relevant model. In the STAM™ model, steatosis, inflammation and ballooning degeneration can all be evaluated, allowing for the accurate calculation of the NAFLD activity score- the same endpoint that is used in clinical trials!
If you choose to conduct a study with us, we will use our years of experience to provide you with a study design that will help you to get your project on track. Please feel free to contact us if you are interested in running a study in our STAM™ model, or if you would just like to learn more about the services we offer here at SMC Laboratories.