Today, we would like to introduce an established positive control – an ALK5 inhibitor - for our Unilateral Ureteral Obstruction (UUO)-induced renal fibrosis model.

This ALK5 inhibitor has an inhibitory effect on the TGF-beta/ALK5 signaling pathway, which plays a central role in renal fibrosis. Due to its antifibrotic abilities, we have established the ALK5 inhibitor as a positive control in our UUO model. Below is the result of fibrosis analysis from an ALK5 inhibitor study in our UUO model.

The UUO model is a great way to study several different aspects of chronic kidney disease, including renal fibrosis, tubular atrophy and inflammatory cell infiltration.
Moreover, This model is a well-established model showing severe fibrosis in the kidney and quick disease onset, making it an attractive model for screening against renal fibrosis.
If you are developing drug candidates targeting fibrosis and kidney disease, we hope you will consider conducting a study utilizing our UUO model.

If you have any questions or requests for more information, please feel free to contact us.