The STAM™ mouse model: a clinically relevant, spontaneous HCC model
We would like to introduce a study published by our client using our STAM™ mouse model (Dow, et al. Proc Natl Acad Sci U S A. 2018).
Title:
Integrative genomic analysis of mouse and human hepatocellular carcinoma
Dow, et al. Proc Natl Acad Sci U S A. 2018
The STAM™ model is a pathological model, with a NASH background, that spontaneously develops hepatocellular carcinoma (HCC). In this paper, the author compared the transcriptomes taken from liver samples of HCC-phase STAM™ mice and human HCC patients. Interestingly, the study found that, when compared with other models (MUP, TAK1, DEN), the HCC that developed in STAM™ mice was the most similar to the genetic profile of human HCC.
If you are considering testing your compound to measure its effect on HCC, we hope you will consider using our STAM™ model. We would be happy to provide you with a custom study plan, tailored to match your specific needs, for either a prophylactic or therapeutic study.
Additionally, you can purchase liver tumor, liver, and plasma samples from the STAM™ mice to use in basic research, just like in this paper.
If you are interested in learning more about our STAM™ model, please do not hesitate to reach out!