Study published in Pharmacol Res Perspect. on the efficacy of the inhibitor of serine palmitoyltransferase (SPT) in STAM™
SMC is proud to announce that Chugai Pharmaceutical Co., Ltd. (JPN) has published the results of their study using our pre-clinical services with the STAM™ mouse in Pharmacol Res Perspect.
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(Hada et al., Pharmacol Res Perspect., 2023)
In this study, they tested the potential of an SPT inhibitor, CH5169356, to suppress HSC activation and ameliorate liver fibrosis. In our STAM™ mouse, they observed that CH5169356 not only had an anti-fibrotic effect, but also alleviated liver inflammation, reducing ALT levels.
The STAM™ mouse is the world's first pathological mouse model to show the progression of NASH to liver cancer, and was developed here at SMC Laboratories. This model shows a similar pathology to human NASH (steatosis → NASH → liver fibrosis → HCC). Therefore, the STAM™ model has been used in many efficacy studies, as well as in basic research.
Also, more than 70 papers have been published using our STAM™ mouse and evaluations have been conducted on various targets and pathways related to NASH-HCC. If you are interested in our experience in evaluating targets of your compound, please contact us.
We would also be happy to arrange a Zoom meeting with our marketing and science team to briefly explain what services we offer and how we might be able to support your project.