Galectin-3 in IPF model
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Galectin-3 is a lectin protein which mediates the development of fibrosis, and has increased levels in macrophages in a variety of organs.
It is reported that Galectin-3 null mice are resistant to liver, lung and heart fibrosis. Currently, a phase 2 clinical trial using a Galectin-3 inhibitor is being conducted in IPF patients.
The results of our histological analysis of Galectin-3 in the IPF model shows the following features.
Galectin-3 in IPF
- Elevates at 3 weeks of age, representing late fibrosis stage in IPF.
- Prominent staining of macrophages expanded due to phagocytosis.
- Shows increase similar to human IPF patients [Nishi et al., Allergol Int., 2007]
We have evaluated over 80 test substances in our IPF model.
If you are interested in learning more about the IPF model we offer, please see our website for more information.