NEWS

The comparison of our STAM™ and other Fibrosis models

  • 2020.02.13
  • UPDATE

We would like to introduced some animal models for liver fibrosis, along with our proprietary NASH-HCC model (STAMTM model).

Liver fibrosis is defined as excessive extracellular matrix deposition preceded by chronic liver injury, which can progress to liver failure.

 

The factors that can cause liver fibrosis include oxidative stress, cholestasis, and nonalcoholic steatohepatitis (NASH).

Therefore, when assessing the efficacy of anti-fibrotic compounds, it is necessary to use a suitable model for the target indication.

 

Please find below the comparison table of STAMTM and other fibrosis models.

 

 Model  STAM1  CCl42,3  BDL2,3  MCD diet2,3
Inducer

 Chemical/Diet

(STZ/HFD)

 Chemical

(Oxidative stress)

 Surgical

(Bile duct ligation)

 Diet

Type

of fibrosis

 NASH

associated fibrosis

 Toxic fibrosis  Cholestatic fibrosis

 NASH

associated fibrosis

Time to develop fibrosis  8 weeks of age~  4 weeks ~  14 days ~  8 weeks ~
Cirrhosis  ×      *
HCC       × ×
Remarks  Mild fibrosis  Dose-dependent fibrosis  High mortality due to biliary leakage  Severe body weight loss

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

[1] Fujii M., et al, Med. Mol. Morphol., 2013, 46:141-52

[2] Am J Physiol Gastrointest Liver Physiol. 2013 ;304(5):G449-68

[3] Liedtke et al. Fibrogenesis & Tissue Repair 2013, 6:19-3

STZ: streptozotocin

HFD: high fat diet

CCl4: carbon tetrachloride

BDL: Bile duct ligation

MCD:methionin-and choline-deficient

*: none reported

 

We can conduct pharmacological studies using the above models could help you progress with the research and development of your compound.