The comparison of our STAM™ and other Fibrosis models
We would like to introduced some animal models for liver fibrosis, along with our proprietary NASH-HCC model (STAMTM model).
Liver fibrosis is defined as excessive extracellular matrix deposition preceded by chronic liver injury, which can progress to liver failure.
The factors that can cause liver fibrosis include oxidative stress, cholestasis, and nonalcoholic steatohepatitis (NASH).
Therefore, when assessing the efficacy of anti-fibrotic compounds, it is necessary to use a suitable model for the target indication.
Please find below the comparison table of STAMTM and other fibrosis models.
(Bile duct ligation)
|Toxic fibrosis||Cholestatic fibrosis||
|Time to develop fibrosis||8 weeks of age~||4 weeks ~||14 days ~||8 weeks ~|
|Remarks||Mild fibrosis||Dose-dependent fibrosis||High mortality due to biliary leakage||Severe body weight loss|
 Fujii M., et al, Med. Mol. Morphol., 2013, 46:141-52
 Am J Physiol Gastrointest Liver Physiol. 2013 ;304(5):G449-68
 Liedtke et al. Fibrogenesis & Tissue Repair 2013, 6:19-3
HFD: high fat diet
CCl4: carbon tetrachloride
BDL: Bile duct ligation
*: none reported
We can conduct pharmacological studies using the above models could help you progress with the research and development of your compound.