NEWS

Relationship between DAMPs/PAMPs and pathogenesis of STAM™ mice

  • 2020.12.25
  • NEWS RELEASE

We would like to share with you the correlation between our proprietary STAM™ model for NASH-HCC, and DAMPs/PAMPs related factors.

 

One of the factors that cause inflammation and fibrosis is damage-associated molecule patterns (DAMPs), which are released when tissues and cells are damaged.

Pathogen-associated molecule patterns (PAMPs) are known to be released by the death or destruction of intestinal and foreign bacteria.

 

DAMPs/PAMPs are recognized by intracellular pattern recognition receptors (PRRs) and induce an immune response.

PRRs are also present in Kupffer cells and hepatic stellate cells in the liver, which receive DAMPs/PAMPs signals and induce inflammation and fibrosis.

 

DAMPs/PAMPs and NASH in humans

It has been reported that DAMPs/PAMPs are associated with the onset and progression of NASH in humans.

In this study, we analyzed S100 protein A8 [1], Toll-like receptor 4 [2], and NLRP3 [3] as examples of DAMPs/PAMPs-related factors.

[1] Serhal R, Biomed Res Int., 2015, [2] Vespasiani-Gentilucci U, Liver Int., 2015, [3] Traber P, PLoS One, 2013

 

The following data is the result of analysis of the above gene expression using our STAM™ model.

In the STAM™ model, we observed a trend of increased expression of all genes, suggesting that this model can be used to evaluate therapeutic agents targeting DAMPs/PAMPs.

 

 

 

 We have obtained time-course RNA sequencing data of this model, and are happy to share the behavior of target factors other than the genes analyzed in this study if requested.