We would like to introduce a paper published by our client using Chronic kidney disease model.

In this paper, the authors showed improvement of the disease state and analyzed the mechanism of UUO-induced kidney fibrosis model by histological analysis and gene expression analysis after the administration of compounds.

About the UUO model

The UUO model used in this paper reproducibly shows the pathological features of interstitial fibrosis, tubular atrophy and inflammatory cell infiltration.

The short duration of the study (2 weeks) makes it an ideal model for screening compounds for renal fibrosis. If you have a compound that has shown anti-fibrotic effects, why not consider testing it using the UUO model?

If you are interested in how to create a UUO model and the conditions it can be used to identify, please check here.