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Today, we would like to introduce a study published by our client using our STAM^TM mouse model (Dow, et al. Proc Natl Acad Sci U S A. 2018).

The STAM^TM model is a pathological model, with a NASH background, that spontaneously develops hepatocellular carcinoma (HCC). In this paper, the author compared the transcriptomes taken from liver samples of HCC-phase STAM^TM mice and human HCC patients. Interestingly, the study found that, when compared with other models (MUP, TAK1, DEN), the HCC that developed in STAM^TM mice was the most similar to the genetic profile of human HCC.

The study reached this conclusion due to the presence of frequent mutations in the Ctnnb1 gene and the downstream pathways, including the Wnt pathway, the cell cycle pathway, and the chromatin modification pathway, all of which are also found in human HCC patients.
Furthermore, HCC in the STAM^TM mice was shown to resemble high-grade proliferative tumors in humans.
These results suggest that HCC in the STAM^TM mice has a high clinical correlation at the genetic level when compared to HCC in human patients.
 
If you are considering testing your compound to measure its effect on HCC, we hope you will consider using our STAM^TM model.
We would be happy to provide you with a custom study plan, tailored to match your specific needs, for either a prophylactic or therapeutic study.
If you are interested in learning more about our STAM^TM model, please do not hesitate to reach out!