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We would like to share some examples of how our NASH-HCC model (STAM^TM model) can be used for fundamental research.

NASH is a disease area in which great demand remains in fundamental research such as elucidation of pathogenic mechanisms and development of new diagnostic methods.

Fundamental research is often conducted using animal disease models, and to use a high clinically correlated model is seen as an important factor.

Our STAM™ model has been used not only for pharmacological studies, but also for various fundamental research studies taking advantage of its high clinical correlation.

Please see below some of the currently published papers on fundamental research using the model.

– Integrative genomic analysis of mouse and human hepatocellular carcinoma

The authors demonstrated that STAM ^TM model was the only mouse model of those examined that closely recapitulated the molecular characteristics of human HCC.

– MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis

By using the model, the authors demonstrated that altered miRNA expression was associated with activation of major hepatocarcinogenesis-related pathways, including the TGF-b, Wnt/b-catenin, ERK1/2,   mTOR, and EGF signaling. In addition, miR-93-5p, miR-221-3p, and miR-222-3 were over-expressed in STAM^TM mice as seen in human HCC.

– Free fatty acid-based low-impedance liver image: a characteristic appearance in nonalcoholic steatohepatitis (NASH)

The acoustic impedance of free fatty acids was measured in liver, and significant decreases was observed in both STAM^TM and human NASH.

– Analysis of amino acid profiles of blood over time and biomarkers associated with non-alcoholic steatohepatitis in STAM mice

By using the model, the authors demonstrated that the composition of free amino acids in the blood changes during the progression from NASH to HCC, and serum amyloid A (SAA) was suggested to be a useful inflammation biomarker associated with NASH.

If you are planning to conduct fundamental research using a murine NASH model, we hope you will consider our STAM^TM model.

We have a variety of other models of inflammation and fibrosis, and we are happy to propose a test plan that meets your needs and requirements.