TAA model: Acute liver failure model
We would like to introduce an acute liver failure (ALF), thioacetamide (TAA)-induced ALF model.
For this model, major endpoints in pharmacology studies include histological assessment of hepatic injury and blood biochemistry (ALT and AST).
The TAA model is as widely used as ALF model and characterized by hepatocellular necrosis caused by an active metabolite of TAA.
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