Silica-induced pulmonary fibrosis model
We would like to introduce you to a Silica-induced pulmonary fibrosis model.
This model is suitable for you if you want to evaluate lung fibrosis over a long period of time (e.g. cell therapy)
The Silica-induced pulmonary fibrosis model reproduces the pathology of the Silicosis, with the production of reactive oxygen species, cell death by apoptosis, and inflammation and fibrosis observed. The Bleomycin-induced lung fibrosis model as an IPF model is a well-known model of lung fibrosis, but the characteristics of the silica model are as follows.
1. Persistence of fibrotic lesions
2. No pathological cause of death
Therefore, the model is particularly suitable when considering long-term administration, with a particular focus on lung fibrosis. The results of pathological changes in the lungs over time are shown below.
The above results show that the fibrotic state is maintained even on day 49 and 63, allowing the efficacy of drug treatment for long-term lung fibrosis to be assessed. The following is an example of a study design.
We also have the results of the anti-fibrotic drug, Nintedanib.
Please contact us if you are interested in more information about the model and the Nintedanib results.