Relationship between DAMPs/PAMPs and pathogenesis of STAM mice
Today, we would like to share with you the correlation between our proprietary STAMTM model for NASH-HCC, and DAMPs/PAMPs related factors.
One of the factors that cause inflammation and fibrosis is damage-associated molecule patterns (DAMPs), which are released when tissues and cells are damaged.
Pathogen-associated molecule patterns (PAMPs) are known to be released by the death or destruction of intestinal and foreign bacteria.
DAMPs/PAMPs are recognized by intracellular pattern recognition receptors (PRRs) and induce an immune response.
PRRs are also present in Kupffer cells and hepatic stellate cells in the liver, which receive DAMPs/PAMPs signals and induce inflammation and fibrosis.
DAMPs/PAMPs and NASH in humans
It has been reported that DAMPs/PAMPs are associated with the onset and progression of NASH in humans.
In this study, we analyzed S100 protein A8 [1], Toll-like receptor 4 [2], and NLRP3 [3] as examples of DAMPs/PAMPs-related factors.
[1] Serhal R, Biomed Res Int., 2015, [2] Vespasiani-Gentilucci U, Liver Int., 2015, [3] Traber P, PLoS One, 2013
The following data is the result of analysis of the above gene expression using our STAMTM model.
In the STAMTM model, we observed a trend of increased expression of all genes, suggesting that this model can be used to evaluate therapeutic agents targeting DAMPs/PAMPs.
We have obtained time-course RNA sequencing data of this model, and are happy to check the behavior of target factors other than the genes analyzed in this study if requested. If you have a target or targets of interest, please get in touch.