Preclinical studies for IBD research: DSS model
We would like to introduce the dextran sulfate sodium (DSS) -induced colitis model, which is a clinically representative mouse model that can be used to conduct drug efficacy studies targeting Inflammatory Bowel Disease.
This model is widely used to elucidate the mechanism of IBD pathogenesis and evaluate drug candidates because of its rapidity, simplicity and many similarities with human IBD. Here at SMC, we are capable of providing different 2 modes of colitis to conduct studies tailored to the needs of our clients and the mode of action of the test substance.
Acute colitis :
Histological features similar to those observed in human IBD, such as mucin and goblet cell depletion, epithelial erosion and an influx of inflammatory cells into lamina propria, can be observed by administering DSS in drinking water for 5 days.
Chronic colitis :
Intestinal fibrosis is established by 5 days of DSS exposure followed by 14 days of housing without DSS exposure.
If you found the above information interesting and would like to learn more about our DSS model, please do not hesitate to contact us.