Pre-clinical studies for NASH: CDAHFD mice model
Today, we would like to give you a brief introduction to the choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD)-induced NASH model.
The CDAHFD model is a non-obese NASH model that is induced by feeding the test animals a choline-deficient, L-amino acid-defined, high-fat diet.
The model reproduces NASH phenotypes such as marked steatosis, immune cell infiltration and pericellular fibrosis, similar to what is observed in human patients.
Due to the complex pathology of NASH in human patients, there has not yet been a model created that can reliably recreate every aspect of it.
Therefore it is believed that in order to accurately evaluate a drug’s efficacy against NASH, it is necessary to use multiple animal models.
In addition to the CDAHFD model, we also have our proprietary model entitled STAMTM, which develops a similar pathology to what is observed in the early stages of human NASH.
If you would like to learn more about either model, or about our services in general, please don’t hesitate to contact us!