Our clients published preclinical data on NASH-HCC on Oncotarget
One of our clients FDA-National Center for Toxicological Research (NCTR) has published the results of a study using STAMTM model on Oncotarget.
Title: “MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis”
By using STAMTM model (NASH-HCC model), they demonstrated that altered miRNA expression was associated with activation of major hepatocarcinogenesis-related pathway, including the TGF-b, Wnt/b-catenin, ERK1/2, mTOR, and EGF signaling. In addition, miR-93-5p, miR-221-3p, and miR-222-3 were over-expressed in STAMTM mice as seen in human HCC.