Obese MASH model
We will introduce the obese MASH model in this article.
Existing MASH (metabolic dysfunction-associated steatohepatitis) models have different characteristics, such as obese/non-obese type, presence/absence of dyslipidemia, and differences regarding the capability to progression to HCC. Since MASH is a complex disease with diverse ways of pathogenesis, it is important to evaluate your test substance in multiple models for different indications i.e. disease backgrounds to best prepare for clinical trials.
As a pioneer in MASH research, SMC Laboratories offers various types of MASH models.
Today, we would like to introduce one of these models, the **Obese MASH Model “GAN Diet Model”**.
Main features of the GAN model:
- Exhibits an obese phenotype
- Dyslipidemia is not pronounced
- Takes approximately 15-25 weeks to develop MASH
- Recapitulates many of the pathological features seen in human MASH
We have acquired a great deal of background data on this model, some of which is available to you upon request.
If you are interested in detailed data on the GAN model, the best combination of models to cover human MASH pathology, or a model comparison chart, please feel free to contact us. We will be happy to provide you with the information and best models for your company’s targets, based on our extensive experience in the field.