Introduction of Dextran Sulfate Sodium (DSS)-Induced Chronic Colitis Mouse Model
Today, we would like to briefly share with you a typical pathological mouse model of Inflammatory Bowel Disease (IBD), the Dextran Sodium Sulfate (DSS)-induced Chronic Colitis Model.
The characteristics of the DSS-induced chronic colitis model are as follows:
– Simple and reproducible disease induction method
– Short disease induction period
– Intestinal fibrosis such as collagen deposition in the lamina propria is observed
It is a useful model for those looking to ① research on the onset and progression of IBD and ② evaluate therapeutic effects and anti-fibrotic properties of drug candidates.
In the chronic colitis model DSS is administered for 5 days, after which the mice are simply housed for the following 14 days.
For examples of representative studies using our DSS-induced chronic colitis model, please see the following published article.
In addition to this IBD model, we provide drug efficacy evaluation services using inflammation/fibrosis models in various organs.
If this is something you might be interested in, please feel free to let me know.