Galectin-3 in IPF model
We would like to introduce Galectin-3, a potential therapeutic target molecule in Idiopathic Pulmonary Fibrosis (IPF) model.
Galectin-3 is a lectin protein which mediates the development of fibrosis, and has increased levels in macrophages in a variety of organs.
It is reported that Galectin-3 null mice are resistant to liver, lung and heart fibrosis.
Currently, a phase 2 clinical trial using a Galectin-3 inhibitor is being conducted in IPF patients.
The results of our histological analysis of Galectin-3 in the IPF model shows the following features.
Galectin-3 in IPF
– Elevates at 3 weeks of age, representing late fibrosis stage in IPF.
– Prominent staining of macrophages expanded due to phagocytosis.
– Shows increase similar to human IPF patients [Nishi et al., Allergol Int., 2007]
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