Column

Today, we would like to introduce a paper published by our client using our non-alcoholic steatohepatitis (NASH) model. (Yang et al., Int J Biol Sci., 2021).

This paper focuses on the prevention of the progression of NASH-derived liver cancer, which has attracted a lot of attention in recent years. After analyzing their target based on gene expression data, they conducted a drug efficacy evaluation study using our NASH-HCC mouse model.

This is not the only paper to report on gene expression analysis using a microarray, as several other papers have reported on the topic as well. The gene expression associated with the target that you are interested in is one of the most important points to consider when conducting a study and is one of the most frequently asked questions by our clients. In particular, we are often asked to provide gene expression data using RNA-seq.

In response to this request, we have acquired gene expression data (RNA-seq) using the STAM^TM model, the world’s first mouse model to show the progression of NASH to liver cancer, developed by SMC Laboratories. The STAM^TM model develops a pathology similar to human NASH (fatty liver → NASH → liver fibrosis → HCC). Why not use the STAM^TM model to examine the gene expression of your target and use it in your research?

If you are interested in the STAM^TM model and the use of gene expression data, please contact us!