2025.03.14

Advanced Non-Clinical COPD Model Mouse for Your Drug Development Needs


In this article, we introduce our COPD model.

 

Why Choose Our COPD Model?

✅Clinically Relevant Evaluations: Our model includes in-life CT scans, lung function tests (FVC via flexiVent, SpO₂ by pulse oximetry), and histological analysis, closely mirroring clinical studies.

✅ Multiple Analyses from a Single Subject: We provide comprehensive assessments, including histology, gene expression, biochemistry, and BALF analysis.

✅ Expert Histopathology for COPD & Fibrosis: Our team has deep expertise in fibrotic/inflammatory lung diseases, ensuring precise evaluation.

✅ Standard of Care Available: Positive control with Roflumilast enables comparative studies.

✅ Optimized PPE Administration: We use a Microsprayer to deliver PPE, ensuring even distribution and consistent disease progression.
 

 

We specialize in non-clinical pharmacology studies, leveraging expertise in inflammation, fibrosis and oncology to support drug discovery.

 

PPE-Induced COPD Model: Key Features

Our model mimics COPD pathology by elastin degradation, immune cell infiltration, and progressive alveolar destruction, leading to airspace enlargement—a hallmark of emphysema (Lloyd Tanner and Andrew Bruce Single, J Innate Immune, 2020).

 

If you are interested in this model, please get in touch with us.