Adenine-induced nephropathy model
We would like to introduce our Adenine-induced nephropathy mouse model, a chronic kidney disease (CKD) model.
Chronic kidney disease (CKD) is a progressive loss in kidney function. Kidney function is measured by Glomerular Filtration Rate (GFR), and blood biomarker (Serum creatinine and BUN).
Due to the continuous decline in kidney function, the condition of CKD patients progresses to chronic kidney failure and then worsens to the point of requiring dialysis or kidney transplantation, but to date there is no fundamental treatment for CKD and the development of therapeutic drugs is desired.
Our Adenine-induced nephropathy model offers the following advantages.
1. Kidney function can be evaluated by blood biochemistry analyses.
2. Histological evaluation of interstitial tubular damage and fibrosis is possible.
3. Evaluation of prevention and treatment efficacy using Telmisartan as a reference control.
This model will allow assessment of renal function using blood markers as well as tissue pathological changes observed after kidney injury. Renal function is used as an endpoint in clinical trials, and this allows for studies to evaluate the efficacy of compounds using the same analysis items as in clinical trials.
For more information, please contact us.