Our Focus on Immuno-Oncology

In the field of immuno-oncology, the STAM™ mouse is the most pathologically suitable model for developing new therapeutic drugs for liver cancer.

The utilization of STAM™ mouse enables non-clinical research for the development of liver cancer therapeutics targeting immune cells, tumor microenvironment, and genetic mutations.

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NEWS RELEASE

A New Phase in MASH Therapeutics: Resmetirom (THR-β Agonist) and Semaglutide (GLP-1 Receptor Agonist)

In 2024, the U.S. FDA approved Resmetirom (a THR-β agonist) as the first therapeutic agent for MASH. In August…

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New

Stem Cell Res Ther.

MicroRNA-4516 in extracellular vesicles-derived mesenchymal stem cells suppressed integrin αV-mediated lung fibrosis ( doi: 10.1186/s13287-025-04559-0.)

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APAP-induced acute liver failure model

The APAP-induced acute liver failure model (Acetaminophen) makes use of the over dosing effects of this widely used antipyretic and analgesic drug. An overdose of APAP can cause severe liver damage resulting in ALF.

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SERVICE

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New

APAP-induced acute liver failure model

ALFmouse

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STAM™ Model | MASH & Fibrosis & HCC

MASH/NASH-HCCmouse

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Bleomycin-induced pulmonary fibrosis model

IPFmouse

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Porcine Pancreatic Elastase (PPE) model

COPDmouse

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CCl4-induced liver fibrosis model

Cirrhosismouse

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BDL model (Bile duct ligation)

mousePBC

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New stage

Our service and disease mouse models bridge the development of the next- Generation Cancer Therapies in the field of Immuno-oncology.

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New stage

SMC Laboratories,Inc.

COMPANY

At SMC Laboratories, we support drug research with our cutting-edge non-clinical pharmacology studies to quickly deliver therapeutic drugs to patients suffering from diseases that cannot be treated with existing drugs.

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PUBLICATION

We, SMC Laboratories, are highly regarded worldwide as a consulting – based CRO that designs tailored to the needs of pharmaceutical companies and research institutions.

NEWS

2025.08.28

PUBLICATION

Publication Announcement: Study Using Our IPF Model

A research article utilizing our bleomycin-induced pulmonary fibrosis (IPF) mouse model has been published in …

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2025.08.15

NEWS RELEASE

A New Phase in MASH Therapeutics: Resmetirom (THR-β Agonist) and Semaglutide (GLP-1 Receptor Agonist)

In 2024, the U.S. FDA approved Resmetirom (a THR-β agonist) as the first therapeutic agent for MASH. In August…

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2025.08.05

PRODUCTS AND SERVICE UPDATE

Clear Negative Correlation Between FVC and Ashcroft Score in Bleomycin-Induced Lung Fibrosis Model

In preclinical drug development for fibrotic lung diseases, the ability to quantitatively and reproducibly ass…

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2025.07.25

PRODUCTS AND SERVICE

New Model Launch: Introduction of the Rat CCl₄-Induced Acute Liver Injury Model

SMC Laboratories is pleased to announce the launch of a new in vivo platform: the rat CCl₄ (carbon tetrachlori…

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2025.07.12

PRODUCTS AND SERVICE

Launch of Rat Disease Model Services

To better meet evolving research needs, SMC Laboratories has officially launched a lineup of preclinical rat d…

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2025.06.07

Column

Chitinase-1 Inhibition Attenuates MASH Progression: A Novel Therapeutic Approach via Metabolic Reprogramming

In May 2025, a collaborative research team from OncoArendi Therapeutics and academic institutions in Poland pu…

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