Our Focus on Immuno-Oncology

In the field of immuno-oncology, the STAM™ mouse is the most pathologically suitable model for developing new therapeutic drugs for liver cancer.

The utilization of STAM™ mouse enables non-clinical research for the development of liver cancer therapeutics targeting immune cells, tumor microenvironment, and genetic mutations.

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NEWS RELEASE

【Breaking News!】 First MASH treatment approved by FDA

On March 14th, The United States Food and Drug Administration (FDA) announced their approval of Rezdiffra (res…

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EVENT

SMC will be exhibiting at The 110th General Meeting of the Japanese Society of Gastroenterology

We are pleased to announce that SMC Laboratories will be exhibiting at The 110th General Meeting of the Japane…

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Cell metab.,

“MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity” (Cell Metab., DOI: 10.1016/j.cmet.2022.10.007., 2022)

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STAM™ model

Our STAM™ model is a model that recapitulates the same disease progression as human MASH/HCC.

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SERVICE

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Our Patented original technologySTAM™ mouse

We are contributing to the world through providing cutting-edge non-clinical pharmacology studies with our unique patented technology, the STAM™ mouse. In order to develop a new drug, it is important to be able to accurately measure the effectiveness of the drug at the non-clinical trial stage. The STAM™ mouse, a model that more accurately reflects human pathology, plays a major role for this purpose.

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COLUMN

2024.04.08

【Hot data】 Resmetirom (MGL-3196) evaluation data available in STAMTM model

MASHResmetiromSTAM

As you may already know, the United States Food and Drug Administration (FDA) announced the approval of Rezdif…

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2024.03.21

What is the best non-clinical liver cancer model with 100% cancer incidence rate and suitable for liver cancer assessment?

If you are considering a drug evaluation study for liver cancer using a mouse model, our STAMTM-HCC/IO+ model …

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2024.03.19

[ Breaking News! ] First MASH treatment approved by FDA

On March 14th, industry-altering news was published. Do you know already what we are talking about? The United…

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2024.03.15

[Existing compounds] that have advanced to clinical trials will accelerate the launch of your drugs.

If you are planning to launch your therapeutic drug, you should select disease mouse models that have shown ac…

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2024.03.15

Pitfalls of [ disease model mice ] that researchers unknowingly fall into.

In order to evaluate your compound, rather than using a general pulmonary fibrosis model that does not match y…

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2024.03.15

| A must for IPF researchers! | Suggestions for the best disease model for your research

If you are considering a drug efficacy study using a mouse model of lung fibrosis, you should use a model that…

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MODEL LINEUP

Introducing disease mice models related to inflammation, fibrosis, metabolic disorder, cancer, and cancer immunity, including the STAM™ mouse, the world's first MASH model mouse developed in our company.

STAM™ model

DISEASE AREAMASH/NASH-HCCTHERAPEUTIC AREAS

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Bleomycin-induced pulmonary fibrosis model

DISEASE AREAIPFTHERAPEUTIC AREAS

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Porcine Pancreatic Elastase (PPE) model

COPDDISEASE AREATHERAPEUTIC AREAS

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CCl4-induced liver fibrosis model

CirrhosisDISEASE AREATHERAPEUTIC AREAS

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Bile duct ligation (BDL) model

DISEASE AREAPBCTHERAPEUTIC AREAS

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TAA-induced acute liver failure model

ALFDISEASE AREATHERAPEUTIC AREAS

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New stage

Our service and disease mouse models bridge the development of the next- Generation Cancer Therapies in the field of Immuno-oncology.

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New stage

SMC Laboratories,Inc.

COMPANY

At SMC Laboratories, we support drug research with our cutting-edge non-clinical pharmacology studies to quickly deliver therapeutic drugs to patients suffering from diseases that cannot be treated with existing drugs.

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PUBLICATION

We, SMC Laboratories, are highly regarded worldwide as a consulting – based CRO that designs tailored to the needs of pharmaceutical companies and research institutions.

NEWS

2024.11.15

PUBLICATION

Our clients’ presentations at AASLD ~The Liver Meeting 2024 ~

Our clients presented data on treatment of MASH using STAMTM model at the AASLD ~The Liver Metting 2024~ (Nove…

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2024.11.05

Case study: Study published in Nature Biotechnology on the effects of TNIK inhibitor in lung and kidney fibrosis models.

We want to introduce a paper by Insilico Medicine, a company that focuses on fibrosis to develop drugs, and af…

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2024.10.24

Preclinical HCC study with positive control, Lenvatinib

We recently obtained new evaluation data on the Lenvatinib in our STAM model and it shows significantly improv…

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2024.10.17

Enhance Research with Our Updated Model Lineup

We are introducing new disease models to our portfolio of preclinical mouse models. Our extensive lineup offer…

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2024.10.07

Results of Resmetirom fibrosis targeting study using STAM™ model

Recently, we have obtained the results of a study of resmetirom for the treatment of fibrosis using STAMTM-HCC…

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2024.08.07

PRODUCTS AND SERVICE PUBLICATION

MOA demonstration #4 【Gut-Liver Axis】｜Evaluation of the efficacy of a compound in the treatment of MASH via the Gut-Liver Axis using STAM™ mice

Today, we introduce the pre-clinical studies in MASH drug development targeting Gut-Liver axis.   In MASH…

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