Our Focus on Immuno-Oncology

In the field of immuno-oncology, the STAM™ mouse is the most pathologically suitable model for developing new therapeutic drugs for liver cancer.

The utilization of STAM™ mouse enables non-clinical research for the development of liver cancer therapeutics targeting immune cells, tumor microenvironment, and genetic mutations.

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NEWS RELEASE

A New Phase in MASH Therapeutics: Resmetirom (THR-β Agonist) and Semaglutide (GLP-1 Receptor Agonist)

In 2024, the U.S. FDA approved Resmetirom (a THR-β agonist) as the first therapeutic agent for MASH. In August…

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Stem Cell Res Ther.

MicroRNA-4516 in extracellular vesicles-derived mesenchymal stem cells suppressed integrin αV-mediated lung fibrosis ( doi: 10.1186/s13287-025-04559-0.)

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Made-to-Order Model

The Made-to-Order Model is a service offered by SMC Laboratories to support clients that are in need of a certain disease model that is not yet available on the market or not part of our current model catalog.

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SERVICE

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APAP-induced acute liver failure model

ALFmouse

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STAM™ Model | MASH & Fibrosis & HCC

MASH/NASH-HCCmouse

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Bleomycin-induced pulmonary fibrosis model

IPFmouse

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Porcine Pancreatic Elastase (PPE) model

COPDmouse

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CCl4-induced liver fibrosis model

Cirrhosismouse

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New stage

Our service and disease mouse models bridge the development of the next- Generation Cancer Therapies in the field of Immuno-oncology.

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New stage

SMC Laboratories,Inc.

COMPANY

At SMC Laboratories, we support drug research with our cutting-edge non-clinical pharmacology studies to quickly deliver therapeutic drugs to patients suffering from diseases that cannot be treated with existing drugs.

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PUBLICATION

We, SMC Laboratories, are highly regarded worldwide as a consulting – based CRO that designs tailored to the needs of pharmaceutical companies and research institutions.

NEWS

2025.10.21

PRODUCTS AND SERVICE

Made to Order Case Study: Establishment of Cecal Cannulation Dosing in a Colitis Model

SMC Laboratories’ MTO (Made to Order) service is designed to address research needs that cannot be met by exis…

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2025.10.14

PRODUCTS AND SERVICE

Made to Order Case Example: Establishment of a Unilateral Ureteral Obstruction (UUO) Model in Guinea Pigs

SMC Laboratories’ MTO (Made to Order) service is designed to address evaluation needs that cannot be met with …

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2025.10.03

Poster Presentation at APASL STC 2025 Tokyo

We are pleased to announce that we presented a poster at APASL STC 2025 Tokyo, under Poster ID PF1-5 10244. Ti…

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2025.10.01

Announcement of Participation in BioJapan 2025 Partnering

We are pleased to announce our participation in BioJapan 2025, which will be held from October 8th to 10th at …

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2025.09.26

PRODUCTS AND SERVICE

Pulmonary Function Assessment in the Elastase-Induced Emphysema Model

At our company, we conduct preclinical evaluations using the elastase-induced emphysema (PPE: porcine pancreat…

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2025.09.12

A New Positive Control Option in the UUO Model: Dapagliflozin

We have confirmed the renoprotective effect of the SGLT2 inhibitor dapagliflozin (20 mg/kg, oral administratio…

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